Aging & Geriatrics
Resources
Basic InformationLatest News
Losing a Spouse Could Speed Brain's DeclineTime Spent on the Links May Lengthen LifeWith Macular Degeneration, 1 Missed Visit to Eye Doc Can Mean Vision LossAgeism Affects People Around the GlobeLife Expectancy in U.S. Increases for First Time in 4 YearsDiets Rich in Fruits, Veggies Could Lower Your Odds for Alzheimer'sBlood Pressure Dips Upon Standing Might Not Be as Dangerous as ThoughtAll in the Timing: Many Get Knee Replacement Too Late or Too SoonWant a Long, Healthy Old Age? A Healthy Middle Age HelpsEven 1 Night's Bad Sleep Can Raise Levels of a Brain 'Marker' for Alzheimer'sSeniors Still Wary of Online Reviews When Picking DoctorsWant to Turn Back the Aging Clock? Train for a MarathonExercise May Keep Your Brain HealthyMore Doubt That Plaques in the Brain Cause Alzheimer'sTo Avoid Falls, Check Your BalanceFatty Diets Tied to Leading Cause of Vision Loss in SeniorsVitamin D Alone Doesn't Prevent Fractures, New Study FindsLove Museums, Theater? The Arts Might Extend Your LifeOut-of-Pocket Costs for Medicare Recipients Will Rise in New Year'Prehab' Before Surgery Helps Speed Seniors' RecoveryRural Seniors Hurt by Lack of Medical SpecialistsHow Well Are You Aging? A Blood Test Might TellTaking Several Prescription Drugs May Trigger Serious Side EffectsCards, Board Games Could Be a Win for Aging BrainsAir Pollution May Up Glaucoma RiskEven in Small Doses, Air Pollution Harms Older AmericansCan Air Pollution Take a Toll on Your Memory?AHA News: Obesity, Other Factors May Speed Up Brain AgingGrandma Isn't So Lonely After AllMuscle in Middle Age Might Help Men's Hearts LaterFish Oil Rx Slows Clogging in ArteriesStatins Won't Harm Aging Brains, and May Even HelpAlmost Half of Older Americans Fear Dementia, Try Untested Ways to Fight ItPeople Who Can't Read Face 2-3 Times Higher Dementia RiskAHA News: Omega-3 May Boost Brain Health in People With a Common Heart DiseaseCommon Muscle Relaxant Could Pose Mental Dangers for SeniorsEducation a Buffer Against Alzheimer's Among Blacks: StudyEven a Little Exercise May Bring a Brain BoostVitamin D is Key to Muscle Strength in Older AdultsMany Older Americans Misuse Antibiotics: PollMany on Medicare Still Face Crippling Medical BillsTest Given at 8 May Predict Your Brain Health in Old AgeNumber of Americans With Dementia Will Double by 2040: Report'Dramatic Increase' Seen in U.S. Deaths From Heart FailureToo Many Seniors Back in Hospital for Infections Treated During First StayFor Seniors, Financial Woes Can Be Forerunner to Alzheimer'sGet Moving: Exercise Can Help Lower Older Women's Fracture RiskDon't Forget These Tips to Boost Your MemoryFamily Can Help Keep Delirium at Bay After SurgeryHow to Manage Your Osteoarthritis
Questions and AnswersVideosLinksBook ReviewsSelf-Help Groups
Related Topics

Depression: Depression & Related Conditions
Elder Care

Even 1 Night's Bad Sleep Can Raise Levels of a Brain 'Marker' for Alzheimer's

HealthDay News
by By Dennis ThompsonHealthDay Reporter
Updated: Jan 8th 2020

new article illustration

WEDNESDAY, Jan. 8, 2020 (HealthDay News) -- Poor sleep has been linked to the development of dementia and Alzheimer's disease, and now a new study suggests a possible reason why.

A small group of young, healthy men deprived of just one night of sleep had higher blood levels of tau protein than when they had a full and uninterrupted night of rest, researchers reported in a study published online Jan. 8 in Neurology.

"This is interesting as accumulation of the protein tau is seen in the brains of individuals afflicted by Alzheimer's disease, or most common forms of dementia," said senior study author Dr. Jonathan Cedernaes, a senior researcher at Uppsala University in Sweden.

The researchers did not find any similar increase in amyloid beta, another brain protein long linked to Alzheimer's, the Swedish researchers said.

The new findings come as Alzheimer's research has started to shift its focus towards tau as a more important cause of brain damage associated with the disease.

Another group of researchers recently reported in the journal Science Translational Medicine that they can predict with reasonable accuracy which brain regions will wither and atrophy in Alzheimer's by identifying the places where tau protein "tangles" have accumulated.

Tau is a protein found in normally active neurons, and it is typically cleared from the brain rapidly, Cedernaes said.

But in Alzheimer's patients, tau sticks together to form tangles that linger in the brain.

For this latest study, researchers recruited 15 men with an average age of 22, all of whom said they regularly get seven to nine hours of quality sleep each night.

The researchers observed each man through two sets of two-day sleep cycles. In the first cycle, they got two good nights of sleep, but in the second cycle they were deprived of sleep for one night.

The men had an average 17% increase in tau levels in their blood after a night of sleep deprivation, compared to an average 2% increase in tau levels after a good night of sleep, the findings showed.

No other biomarkers associated with Alzheimer's showed a similarly significant change, including amyloid beta, according to the report.

At this point, scientists don't know why tau might build up in the bloodstream of people who've had bad sleep, Cedernaes said.

"When neurons are more active, they secrete more tau," Cedernaes said. "It may be that when we remain awake for extended periods of time -- much longer than the 15 to 18 daily hours that we are supposed to -- then this increases levels of tau in the brain to a point where it exceeds the brain's ability to clear it effectively for a given 24-hour period."

Sleeplessness might also affect the way in which the body clears tau protein from the brain, said Keith Fargo, director of scientific programs and outreach at the Alzheimer's Association.

"Everyone produces amyloid and tau in their brain every day, and the brain is supposed to take out the trash," Fargo said. "The thinking is if the sleep is disrupted in some way, the processes involved in taking out the trash are disrupted."

Another possibility is that tau is released from brain cells when they are damaged, Fargo added. For example, head trauma can increase blood levels of tau.

"If a brain cell dies, the tau can spill out of the brain cell," Fargo explained. "Maybe what you're seeing is a loss of brain cell integrity if you're not sleeping."

Although the findings are interesting, Fargo noted that this was a very small study involving only young people.

Larger studies involving middle-aged folks who have poor sleep for more than just one night -- perhaps a week or a month -- would provide even better data that could be more closely tied to dementia and Alzheimer's, Fargo said.

Cedernaes agreed that more research is needed to come to a better understanding of this association.

"At present, we do not know exactly what these changes represent, nor do we have any data indicating that a single or even multiple nights of sleep loss lead to some permanent harmful event in the brain," Cedernaes said. "Many individuals are forced to undergo repeated bouts of sleep loss and maintain perfect cognition throughout life."

More information

The Alzheimer's Association has more about risk factors for Alzheimer's.




Facebook

Amazon Smile

 

Children and Adult services are available now with no wait time.  

Please contact HBH at 860-548-0101, option 2.

 


powered by centersite dot net