Medical Disorders
Resources
Basic InformationLookupsLatest News
Drop in Life Expectancy From COVID Much Worse for Black, Hispanic AmericansInnovative Kidney Donor 'Voucher' System Is Saving LivesMental Confusion an Early Warning Sign of Severe COVID-19COVID Caused Biggest Drop in U.S. Life Expectancy Since World War IIClot-Removing Procedure Can Sometimes Backfire for Stroke PatientsFDA to Add Warning to Pfizer, Moderna Vaccines About Rare Heart Issues in YoungAHA News: Silent Heart Attacks All Too Common, and Often OverlookedRash, Itch After COVID Vaccine Rare & Quickly ResolvesStudy Suggests COVID Vaccine Booster Shots Will Be NeededNo Need for Blood Thinners in Patients Sick at Home With COVID-19Heart Issues in Young COVID Vaccine Recipients Rare, Usually Mild and Quickly Resolve: ExpertsMore E-Scooter Rideshares, More InjuriesMore Than Half of People With Asthma Aren't Seeing a SpecialistAutopsy Study Shows How COVID Harms the BrainCOVID Deaths Drop to New Lows in U.S., While Vaccination Rates ClimbNot-So-Happy-Birthdays: Parties Helped Spread COVID, Study FindsAHA News: Should Rare Cases of Heart Inflammation Put Your COVID-19 Vaccine Plans on Hold?Obesity in Teens Raises Adult Diabetes Risk, Even After Weight LossNew Genetic Insights Into Cause of ALSScreen All Kids for Heart Problems, Pediatricians' Group SaysIn 11 States, Seniors' Low Vaccination Rates a 'Powder Keg' for New CasesSickle Cell Plagues Many Black Americans, But There's Hope for Better TreatmentsSurvivors' Plasma Helps Blood Cancer Patients Battle COVID-19Hospitals: One Reason COVID Is More Lethal for Black AmericansMany 'High Priority' Patients Aren't Getting Put on Kidney Transplant ListsU.S. to Spend $3.2 Billion to Help Develop Antiviral Pills for COVIDRed Cross Warns of Severe Blood ShortageHand Sanitizer Vapors Can Cause Nausea, DizzinessPfizer, Moderna Vaccines Do No Harm to Male Fertility: StudyLess Than 1% of People Who've Had Severe COVID Get Re-InfectedMold a Big Threat to People With COPDWhat Works Best to Ease Migraines?Pandemic Silver Lining: Fewer Dangerous Flare-Ups for COPD PatientsIs Zinc a Friend or Foe to Kidney Stones?Strict Rest Not Recommended After Sports-Linked Concussion, Experts SayEven Good Weather Didn't Lift Lockdown Blues: StudyU.S. ​COVID Death Toll Tops 600,000Third Dose of COVID Vaccine Boosts Protection in Transplant RecipientsCould a Type of Statin Raise Dementia Risks?Many U.S. Seniors May Need Better Knee Arthritis CareAfter COVID, Many Americans Are Struck by New Maladies: StudyCataracts: Common, and Easy to TreatThere Are Many Good Reasons for Kids to Get the COVID VaccineBabies Produce Strong Immune Response to Ward Off COVID-19: StudyNovavax's COVID Vaccine Shines in Latest TrialAHA News: U.S. Appears to Lose Ground in Controlling High Blood PressureWeight-Loss Surgeries Used Least in U.S. States That Need Them MostObesity Could Raise Odds for 'Long-Haul' COVID SymptomsSmokers, Obese People Need Major Heart Interventions Earlier in LifeOld Age No Bar to Successful Heart Transplant, Study Finds
Questions and AnswersVideosLinksBook Reviews
Related Topics

Cancer
Men's Health
Women's Health

'Breakthrough' COVID Infections May Be Common in Vaccinated Transplant Patients

HealthDay News
by Ernie Mundell
Updated: Jun 8th 2021

new article illustration

TUESDAY, June 8, 2021 (HealthDay News) -- New research suggests that many people who've undergone an organ transplant do not get an immune response from COVID-19 vaccines that's strong enough to ward off a "breakthrough" infection.

In a new review of 14 such cases, these breakthrough COVID-19 infections occurred in 10 recipients of new kidneys, two liver recipients, one lung recipient and one heart recipient, said a research team working in New York City.

Eight of them had completed the Pfizer COVID-19 two-dose vaccine series, five had completed the Moderna two-dose series and one had gotten the Johnson & Johnson single-dose vaccine, according to the team from NYU Langone.

"We need additional studies to determine why these breakthrough cases may be occurring and how to prevent them, but also want to ensure that transplant patients continue to take all the proper precautions that have been protecting them through the pandemic," Dr. Robert Montgomery, director of the hospital's Transplant Institute, said in a Langone news release.

Transplant patients typically take immune-suppressing drugs after receiving a donor organ, to help ward off organ rejection. But it's thought that use of the drug could have a side-effect of rendering vaccines less effective.

All of the patients in the new study were taking various immunosuppressant drugs including: prednisone, calcineurin inhibitor (13), antimetabolite agent (13), belatacept (1) and mTOR inhibitor (1), Montgomery's team noted.

Seven patients were hospitalized after their breakthrough infections, with five patients developing severe COVID-19 illness.

The heart transplant recipient, who was among those who developed severe COVID-19, died, according to the study published online recently in the journal Transplantation.

"These are troubling findings for transplant patients who may think they are protected after being fully vaccinated," Montgomery said.

The trials that led up to approval of COVID-19 vaccines had "excluded immunocompromised patients," according to study co-author Dr. Sapna Mehta, an infectious disease specialist and clinical director of the institute.

Furthermore, "a recent report found only 17% of transplant recipients had any detectable anti-spike antibodies after the first mRNA vaccine compared to 100% of non-immunocompromised patients having antibody responses in clinical trials," she said.

Anti-spike refers to the "spike protein" on the SARS-CoV-2 coronavirus that is the prime target of approved vaccines.

"Further follow-up of the same cohort of transplant recipients shows antibody responses improved to 54% after their second vaccine dose," Mehta said, but that level is still "far below response rates in non-immunocompromised patients."

Mehta noted that there are 10 million Americans with compromised immune systems.

More study is needed to determine the best vaccine dosages for these people, "who continue to live under heightened pandemic precautions while their level of vaccine-related immunity remains uncertain," Mehta said.

More information

The American Society of Transplantation has more on COVID-19.

SOURCE: NYU Langone Health, news release, May 2021




Facebook

Amazon Smile

 

Children and Adult services are available now with no wait time.  

Please contact HBH at 860-548-0101, option 2.

 


powered by centersite dot net